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I've just discovered that Gal4 degradation (essential for function as an activator, which erm, it is and an example of how proteasome mediated turnover of activators can induce gene activation by various mechanisms) is regulated by the E3 ligase (adds ubiquitin to the substrate and marks for destruction) Grr1!!! How brilliant is that?

At this point it's worth adding that the RING finger domain in TFs stands for Really Interesting New Gene. No, seriously. It does. And SHH is Sonic Hedgehog Gene, which is involved in growth. And the scaramanga gene, that controls the development of breasts and therefore can somtimes go wrong, leading to third nipple formation etc (and I think it's been implicated in breast cancer pretty recently too) is named after the James Bond villan. Who had a third nipple.

And I've just found a paper called Uteroglobin Gene Transcription: What's the RUSH? (RUSH is the type of transcription factor involved.....oh dear. Genetics jokes are terrible.)